Quellennachweise

 

Interessierte Leser können in diesen Quellen weitere Informationen zum Hintergrund vor allem zur Wirkung von Forskolin in Bezug auf die Haut finden (1-11), sowie aktuelle Arbeiten zum Thema Hyaluronsäure (12-14). 

Die Rolle des cAMP in der gesunden Haut habe ich auch in meinem Buch  „Das Psoriasis-Syndrom“ ausführlich beschrieben, mit vielen weiteren Literaturangaben  (ISBN 978-3745088403, eBook ISBN 978-3754937891).



  1. Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation; Alexandra Amaro-Ortiz, Betty Yan and John A. D’Orazio (Molecules 2014, 19, p.6202-6219; https://doi.org/10.3390/molecules19056202) 
  2. In Vitro Skin Diffusion Study of Pure Forskolin versus a Forskolin-Containing Plectranthus barbatus Root Extract; Jing Chen†, Dana C. Hammell, Malinda Spry, John A. D’Orazio, and Audra L. Stinchcomb (Nat Prod. 2009 April ; 72(4): 769–771. https://doi.org/10.1021/np800541k)
  3. Forskolin Protects Keratinocytes from UVB-Induced Apoptosis and Increases DNA Repair Independent of its Effects on Melanogenesis; Thierry Passeron, Takeshi Namiki, Hélène J. Passeron, Elodie Le Pape and Vincent J. Hearing (Journal of Investigative Dermatology (2009) 129, 162–166;https://doi.org/10.1038/jid.2008.182)
  4. Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 2; Rawiya H. Alasbahi, Matthias F. Melzig (Planta Med 2010; 76: 753–765. DOI http://dx.doi.org/ 10.1055/s-0029-1240919)
  5. Die Rolle von Mineralien im menschlichen Körper; V. S. Kislichenko (Ukrainische Pharmazeutische Akademie, Charkow, 2022)
  6. Forskolin, a Hedgehog signal inhibitor, inhibits cell proliferation and induces apoptosis in pediatric tumor cell lines; Hiroaki Yamanaka, Takaharu Oue, Shuichiro Uehara and Masahiro Fukuzawa (Molecular Medicine rePorTS 3: 133-139, 2010 https://doi.org/10.3892/mmr_00000230)
  7. Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin; Eri Makinodan, Alexander G. Marneros (Experimental Dermatology Volume21, Issue11 November 2012 Pages 847-852 https://doi.org/10.1111/exd.12016)
  8. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells; Jesse Lyonsa, Boris C. Bastiana,b, and Frank McCormick (PNAS  August 20, 2013 vol. 110 no. 34 13845–13850 www.pnas.org/cgi/doi/10.1073/pnas.1201917110)
  9. Enhancement of UV-induced nucleotide excision repair activity upon forskolin treatment is cell growth-dependent; Jeong-Min Lee, Jeong-Min Park & Tae-Hong Kang (BMB Rep. 2016; 49(10): 566-571 https://doi.org/10.5483/BMBRep.2016.49.10.097)
  10. The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?; Luigi Sapio, Monica Gallo, Michela Illiano, Emilio Chiosi, Daniele Naviglio, Annamaria Spina, Silvio Naviglio (J. Cell. Physiol. 232: 922–927, 2017 https://doi.org/10.1002/jcp.25650)
  11. MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair; Viki B. Swope and Zalfa A. Abdel-Malek (Int. J. Mol. Sci. 2018, 19, 2667; https://doi.org/10.3390/ijms19092667)
  12. Skin antiaging effects of a multiple mechanisms hyaluronan complex; Chen F, Guo X, Wu Y.  (Skin Res Technol. 2023;29(6):e13350. https://doi.org/10.1111/srt.13350)
  13. Adenosine 2A receptor promotes collagen production by human fibroblasts via pathways involving cyclic AMP and AKT but independent of Smad2/3;Miguel Perez-Aso, Patricia Fernandez, Aránzazu Mediero, Edwin S. Chan, Bruce N. Cronstein (FASEB J. 2014 Feb;28(2):802–812. https://doi.org/10.1096/fj.13-241646
  14. Regulation of hyaluronan production by β2 adrenergic receptor signaling; Yoshiyuki Kuroda, Hideyoshi Higashi (Biochemical and Biophysical Research Communications, Volume 575, 20 October 2021, Pages 50-55. https://doi.org/10.1016/j.bbrc.2021.08.056)